Identity
SHLP3 is small humanin-like peptide 3, distinct from SHLP2.
Cell experiments in the cited discovery study.
Peptide library
SHLP3
Your guide to this compound.
Mechanism illustrationEnlarge
Evidence in perspective
Laboratory apoptosis, oxidative-stress and mitochondrial measures are surrogate observations. They do not demonstrate a clinical anti-aging, metabolic or immune benefit.
About this assessment
Existing source snapshot critically reassessed.
Based on the selected source scope described in this profile, often an indexed abstract. Full methods and clinician sign-off remain pending; no systematic-review claim.
Editorial assessment · 2026-09-07
Who was studied
Cell experiments in the cited discovery study.
What the sources found
SHLP3 reduced apoptosis and oxidative stress and altered mitochondrial activity in laboratory models.
Cell experiments in the cited discovery study.
Regulatory scope
No jurisdiction-specific marketing authorization has been verified in this snapshot; study publication is not regulatory approval.
What remains unknown
These findings do not establish human efficacy, long-term safety, or equivalence to products sold under this name. This is a focused source snapshot, not an exhaustive clinical review.
How it works
SHLP3 is small humanin-like peptide 3, distinct from SHLP2.
Read the study-specific findings and limitations in Medical. Mechanistic activity does not establish a treatment benefit.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Reported adverse effects
- The cited evidence does not establish comprehensive human adverse-event rates.
Contraindications
- A complete clinical contraindication profile has not been established in this review.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Sources used for this snapshot
Claim-by-claim evidence
Findings
SHLP3 reduced apoptosis and oxidative stress and altered mitochondrial activity in laboratory models.
Cell experiments in the cited discovery study.
References
Cobb et al. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. 2016.
PMID: 27070352
Catalog review date: Sep 6, 2026. This date alone does not establish independent clinical review.