Identity
PNC-28 combines a p53-derived segment with a cell-penetrating sequence; it is distinct from PNC-27.
Tumor cell models and nude mice bearing transplanted pancreatic tumors.
Peptide library
PNC-28
Your guide to this compound.
Mechanism illustrationEnlarge
Evidence in perspective
Suppressed growth of transplanted pancreatic tumors in mice is a preclinical signal. It does not establish benefit or safety in people with cancer and cannot replace clinical oncology care.
About this assessment
Existing source snapshot critically reassessed.
Based on the selected source scope described in this profile, often an indexed abstract. Full methods and clinician sign-off remain pending; no systematic-review claim.
Editorial assessment · 2026-09-07
Who was studied
Tumor cell models and nude mice bearing transplanted pancreatic tumors.
What the sources found
The study reported suppression of tumor growth in mice. It did not test treatment efficacy in people.
Tumor cell models and nude mice bearing transplanted pancreatic tumors.
Regulatory scope
No jurisdiction-specific marketing authorization has been verified in this snapshot; study publication is not regulatory approval.
What remains unknown
These findings do not establish human efficacy, long-term safety, or equivalence to products sold under this name. This is a focused source snapshot, not an exhaustive clinical review.
How it works
PNC-28 combines a p53-derived segment with a cell-penetrating sequence; it is distinct from PNC-27.
Read the study-specific findings and limitations in Medical. Mechanistic activity does not establish a treatment benefit.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Reported adverse effects
- The cited evidence does not establish comprehensive human adverse-event rates.
Contraindications
- A complete clinical contraindication profile has not been established in this review.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Sources used for this snapshot
Claim-by-claim evidence
Findings
The study reported suppression of tumor growth in mice. It did not test treatment efficacy in people.
Tumor cell models and nude mice bearing transplanted pancreatic tumors.
References
Michl et al. PNC-28 blocks pancreatic cancer cell growth in vivo. 2006.
PMID: 16688716
Catalog review date: Sep 6, 2026. This date alone does not establish independent clinical review.