Peptide library
Your guide to this compound.
The large cardiac-surgery trial’s neutral outcome carries more clinical weight for that indication than mouse endurance experiments. Neither the disease population nor the IV trial product validates exercise enhancement in healthy users.
Existing source snapshot critically reassessed.
Based on the selected source scope described in this profile, often an indexed abstract. Full methods and clinician sign-off remain pending; no systematic-review claim.
Editorial assessment · 2026-09-07
Source 1 · pubmed.ncbi.nlm.nih.gov
Source 2 · pubmed.ncbi.nlm.nih.gov
Mouse metabolic experiments; separately, adults undergoing coronary artery bypass graft surgery.
The 3,080-participant RED-CABG trial stopped for futility and did not improve its primary composite outcome; mouse exercise results cannot establish benefit for healthy people.
Exact study context; no performance-use extrapolation.
A targeted source review, not a complete clinical monograph. Product stability, long-term safety, interactions and jurisdiction-specific authorization require further verification. Research findings do not validate commercial vials.
AICA-riboside is used to study cellular energy signalling. Narkar and colleagues investigated AMPK-related metabolic responses and endurance in mice.
AICA-riboside is used to study cellular energy signalling. Narkar and colleagues investigated AMPK-related metabolic responses and endurance in mice.
Exact study context; no performance-use extrapolation.
This catalog identifies human research. A trial can be early, small or negative; its existence does not establish approval or benefit for every proposed use. Check the study population and outcomes.
This catalog identifies human research. A trial can be early, small or negative; its existence does not establish approval or benefit for every proposed use. Check the study population and outcomes.
Source 1 · pubmed.ncbi.nlm.nih.gov
Source 2 · pubmed.ncbi.nlm.nih.gov
AICAR in this entry means acadesine, or AICA-riboside: a non-peptide research compound. Mouse exercise experiments and human cardiac-surgery trials answer different questions; neither establishes a personal endurance or longevity regimen.
Exact study context; no performance-use extrapolation.
AICA-riboside is used to study cellular energy signalling. Narkar and colleagues investigated AMPK-related metabolic responses and endurance in mice.
Exact study context; no performance-use extrapolation.
The 3,080-participant RED-CABG trial stopped for futility and did not improve its primary composite outcome; mouse exercise results cannot establish benefit for healthy people.
Exact study context; no performance-use extrapolation.
Historical CABG research used a continuous IV infusion of 0.05 or 0.1 mg/kg/min for 7 hours, plus acadesine in cardioplegia. These are infusion rates in a surgical trial, not bolus doses or a subcutaneous regimen.
Exact study context; no performance-use extrapolation.
A human IV disposition study exists, but no numeric half-life is supplied here until its full pharmacokinetic methods and analyte are reviewed.
Exact study context; no performance-use extrapolation.
Narkar et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008.
Mangano et al. Acadesine in coronary artery bypass surgery. Anesthesiology. 1995.
Newman et al. RED-CABG randomized controlled trial. JAMA. 2012;308:157–164.
Acadesine: disposition and metabolism of an adenosine-regulating agent. J Clin Pharmacol. 1993.
Catalog review date: Sep 6, 2026. This date alone does not establish independent clinical review.