Identity
SHLP2 is small humanin-like peptide 2, a mitochondrial-derived research peptide.
Cell experiments and rodent metabolic studies.
Peptide library
SHLP2
Your guide to this compound.
Mechanism illustrationEnlarge
Evidence in perspective
Cell protection and rodent metabolic experiments support biological investigation. Endogenous-peptide associations and treatment experiments in another species cannot establish benefit from human injection.
About this assessment
Existing source snapshot critically reassessed.
Based on the selected source scope described in this profile, often an indexed abstract. Full methods and clinician sign-off remain pending; no systematic-review claim.
Editorial assessment · 2026-09-07
Who was studied
Cell experiments and rodent metabolic studies.
What the sources found
SHLP2 affected cellular survival and mitochondrial metabolism; rodent work examined insulin sensitivity.
Cell experiments and rodent metabolic studies.
Regulatory scope
No jurisdiction-specific marketing authorization has been verified in this snapshot; study publication is not regulatory approval.
What remains unknown
These findings do not establish human efficacy, long-term safety, or equivalence to products sold under this name. This is a focused source snapshot, not an exhaustive clinical review.
How it works
SHLP2 is small humanin-like peptide 2, a mitochondrial-derived research peptide.
Read the study-specific findings and limitations in Medical. Mechanistic activity does not establish a treatment benefit.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Reported adverse effects
- The cited evidence does not establish comprehensive human adverse-event rates.
Contraindications
- A complete clinical contraindication profile has not been established in this review.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Sources used for this snapshot
Claim-by-claim evidence
Findings
SHLP2 affected cellular survival and mitochondrial metabolism; rodent work examined insulin sensitivity.
Cell experiments and rodent metabolic studies.
References
Cobb et al. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. 2016.
PMID: 27070352
Nashine et al. SHLP2 in an age-related macular degeneration cell model. 2018.
PMID: 30310092
Catalog review date: Sep 6, 2026. This date alone does not establish independent clinical review.