Identity
Copper-free GHK is Gly-His-Lys; it is distinct from the copper complex GHK-Cu.
Source-specific finding, not full clinical sign-off.
Peptide library
GHK
Your guide to this compound.
Mechanism illustrationEnlarge
Evidence in perspective
Human keratinocytes in culture are not treated human participants. Copper-free GHK must remain separate from GHK-Cu, and skin-model markers do not establish clinical wound repair.
About this assessment
Existing source snapshot critically reassessed.
Based on the selected source scope described in this profile, often an indexed abstract. Full methods and clinician sign-off remain pending; no systematic-review claim.
Editorial assessment · 2026-09-07
Who was studied
Cultured human keratinocytes and reconstructed skin models.
What the sources found
Cell proliferation and selected skin-model markers changed. These were not clinical wrinkle or wound-healing outcomes.
Regulatory scope
Current authorization must be checked for the exact product, indication and jurisdiction.
What remains unknown
Limited selected-source check, not an exhaustive review. Full methods, complete safety, exact formulation/route pharmacokinetics, stability and current jurisdictional authorization remain outstanding.
How it works
Copper-free GHK is Gly-His-Lys; it is distinct from the copper complex GHK-Cu.
Read the source-specific findings; biological activity is not equivalent to a clinical treatment benefit.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Reported adverse effects
- Cell-culture findings do not establish injectable safety or clinical benefit.
Source-specific finding, not full clinical sign-off.
Contraindications
- Full clinical contraindication and interaction assessment remains outstanding.
Preclinical research
The catalog primarily cites laboratory or animal research. Human benefit, a safe dose and long-term risks cannot be inferred from those findings.
Sources used for this snapshot
Claim-by-claim evidence
Benefits
Cell proliferation and selected skin-model markers changed. These were not clinical wrinkle or wound-healing outcomes.
Source-specific finding, not full clinical sign-off.
Adverseeffects
Cell-culture findings do not establish injectable safety or clinical benefit.
Source-specific finding, not full clinical sign-off.
References
Stem cell recovering effect of copper-free GHK in skin. 2012.
PMID: 23019153
Catalog review date: Sep 7, 2026. This date alone does not establish independent clinical review.