Apraglutide

Evidence in perspective

Very small crossover and open-label absorption studies are exploratory; no formal sample-size calculation and multiple unadjusted comparisons limit confidence. Fluid absorption does not itself establish durable independence from parenteral support.

Who was studied

Small adult short bowel studies, including an eight-person randomized crossover trial.

What the sources found

The small trials reported improvements in fluid and nutrient absorption.

What remains unknown

Small samples and short treatment periods limit certainty. This is not evidence for use in people without intestinal failure.

How it works

GLP-2 receptor activation promotes intestinal absorptive function.

GLP-2 receptor activation promotes intestinal absorptive function. Small samples and short treatment periods limit certainty. This is not evidence for use in people without intestinal failure.

Human trials

This catalog identifies human research. A trial can be early, small or negative; its existence does not establish approval or benefit for every proposed use. Check the study population and outcomes.

Understanding the evidence

Reported adverse effects

• Stoma complications, nausea, flatulence and abdominal pain were reported in the small metabolic-balance trial.